Redistribution of myocardial blood flow in chronic ischemia under the effects of pharmacological agents

In the experiments with anesthetized dogs under chronic myocardial ischemia the effect of propranolol, diltiazem, lithium and sodium hydroxybutyrate on the myocardial blood flow redistribution was studied with the help of ultrasonic method. The redistribution was estimated by the ratio change of blo...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 111; no. 4; p. 359
Main Authors Chichkanov, G G, Matsievskiĭ, D D, Tolmacheva, E A, Grigor'eva, E K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.1991
Subjects
Animals
Coronary Circulation - drug effects
Coronary Disease - diagnostic imaging
Coronary Disease - drug therapy
Coronary Disease - physiopathology
Diltiazem - pharmacology
Dogs
Female
Hydroxybutyrates - pharmacology
Lithium - pharmacology
Male
Propranolol - pharmacology
Time Factors
Ultrasonography
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Summary:In the experiments with anesthetized dogs under chronic myocardial ischemia the effect of propranolol, diltiazem, lithium and sodium hydroxybutyrate on the myocardial blood flow redistribution was studied with the help of ultrasonic method. The redistribution was estimated by the ratio change of blood flows in veins which drain blood directly from the focus of myocardial ischemia and total myocardial of left ventricular (v cardiac magna). It was established that propranolol increases the ratio and diltiazem decreases it. Some differences in the effect of antihypoxic drugs were revealed. Sodium hydroxybutyrate redistributed the blood flow in favour of the focus of myocardial ischemia and lithium hydroxybutyrate increased the blood flow both in the focus of myocardial ischemia and in the conditionally-intact region of myocardium of left ventricular.
ISSN:0365-9615