The L-DOPA test in patients with obsessive fear neurosis

Three groups of patients with morbid fear neurosis, dissimilar in prevailing of either adrenaline or noradrenaline excretion, were identified using the complex method of sympathoadrenal system (SAS) examination. The test with 0.1 g L-DOPA loading demonstrated the high rate of synthesis and high reac...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 34; no. 1; p. 115
Main Authors Vasil'ev, V N, Chugunov, V S, Derbeneva, L M, Eremeev, M S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1988
Subjects
Adrenal Cortex - physiopathology
Adult
Dopamine - urine
Epinephrine - urine
Female
Humans
Levodopa - urine
Male
Middle Aged
Norepinephrine - urine
Obsessive-Compulsive Disorder - diagnosis
Obsessive-Compulsive Disorder - physiopathology
Phobic Disorders - diagnosis
Phobic Disorders - physiopathology
Sympathetic Nervous System - physiopathology
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Summary:Three groups of patients with morbid fear neurosis, dissimilar in prevailing of either adrenaline or noradrenaline excretion, were identified using the complex method of sympathoadrenal system (SAS) examination. The test with 0.1 g L-DOPA loading demonstrated the high rate of synthesis and high reactivity of SAS in the first two groups with the adrenal type of SAS functioning as well as an increased hydroxylation in the course of synthesis of catecholamines. These anomalies were accompanied by impairments of adrenaline metabolism in the second group. A decreased reactivity of SAS in morning crises and elevated reactivity--during day and evening crises were observed in the third group of patients, characterized by the noradrenaline type of the system functioning as well as by presence of noradrenaline crises.
ISSN:0042-8809