The expression of antigens, detectable with ICO-series monoclonal antibodies, on the surfaces of cells forming granulocyte and macrophage colonies in semiliquid agar

The expression of antigens on granulocyte-macrophagal colony-forming cells of patients with nonhematological diseases was studied. Treatment of bone marrow cells with murine monoclonal antibodies ICO-1 and ICO-11 led to statistically significant inhibition of the number of growing colonies. Monoclon...

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Bibliographic Details
Published inEksperimentalʹnaja onkologija Vol. 11; no. 1; p. 46
Main Authors Savel'eva, E V, Kharlamova, L A, Baryshnikov, A Iu, Agafonov, V A, Tupitsyn, N N
Format Journal Article
LanguageRussian
Published Ukraine 1989
Subjects
Agar
Antibodies, Monoclonal - immunology
Antigens, Differentiation - analysis
Antigens, Surface - analysis
Bone Marrow - immunology
Bone Marrow Cells
Cells, Cultured
Colony-Forming Units Assay
Complement System Proteins - immunology
Granulocytes - immunology
Humans
Macrophages - immunology
Stem Cells - immunology
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Summary:The expression of antigens on granulocyte-macrophagal colony-forming cells of patients with nonhematological diseases was studied. Treatment of bone marrow cells with murine monoclonal antibodies ICO-1 and ICO-11 led to statistically significant inhibition of the number of growing colonies. Monoclonal antibodies ICO-02, ICO-10, ICO-GM-1 and ICO-G-2 had no such effect.
ISSN:0204-3564