An evaluation of the acute in vivo toxicity of benzylidenechroman-4-ones, 1-thiobenzylidenechroman-4-ones and benzylidenetetralones

A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antif...

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Published inDrug and chemical toxicology (New York, N.Y. 1978) Vol. 13; no. 2-3; p. 195
Main Authors Al-Nakib, T M, Miller, N J, Rashid, S, Meegan, M J
Format Journal Article
LanguageEnglish
Published United States 1990
Subjects
Animals
Antifungal Agents - administration & dosage
Antifungal Agents - toxicity
Benzylidene Compounds - toxicity
Chromones - toxicity
Dose-Response Relationship, Drug
Female
Injections, Intraperitoneal
Male
Mice
Mice, Inbred Strains
Motor Activity - drug effects
Reflex - drug effects
Sex Characteristics
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Summary:A series of new compounds were evaluated for acute in vivo toxicity. Their synthesis and antifungal activity have previously been described by us. The naturally occurring class of compounds to which they belong - the benzylidenechroman-4-ones - have been identified as a potential source of new antifungal agents. These compounds were found to be less toxic, as judged by acute toxicity, than existing commercially available antifungals. A number of conclusions can be drawn about the relationship of structural changes in this series of compounds to increases or decreases in acute toxicity.
ISSN:0148-0545
1525-6014