Aseptic necrosis of the head of the femur in Cooley's disease

The incidence of aseptic necrosis of femoral head in homozygous beta-thalassaemia (Cooley's anaemia)--which is indeed significantly high--is not satisfactorily referred in late literature regarding haemolytic syndromes. Therefore, 4 cases of osteonecrosis of femoral head, recently recognized in...

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Bibliographic Details
Published inRadiologia medica Vol. 72; no. 3; p. 102
Main Authors Orzincolo, C, Scutellari, P N, Bariani, L, Pinca, A, Beccari, G, Castaldi, G
Format Journal Article
LanguageItalian
Published Italy 01.03.1986
Subjects
Adolescent
Adult
Female
Femur Head - blood supply
Femur Head Necrosis - diagnostic imaging
Femur Head Necrosis - etiology
Femur Head Necrosis - pathology
Humans
Ischemia - complications
Legg-Calve-Perthes Disease - pathology
Male
Radiography
Thalassemia - complications
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Summary:The incidence of aseptic necrosis of femoral head in homozygous beta-thalassaemia (Cooley's anaemia)--which is indeed significantly high--is not satisfactorily referred in late literature regarding haemolytic syndromes. Therefore, 4 cases of osteonecrosis of femoral head, recently recognized in a series of 280 patients affected by Cooley's anaemia (14.5 0/00) are presented, and a review of hypotheses about the pathogenesis of the lesions is considered. In Cooley's anaemia, the skeletal lesion (osteoporosis) must be believed as a propitious state, in which some other pathogenetic events (i.e. local ischemia, bony age, etc.) and microtraumas overlap. In any case, characteristic blood circulation of the femoral head is the "conditio sine qua non" in developing osteonecrosis.
ISSN:0033-8362