The state of the protease-inhibitor system in the bronchoalveolar lavage of patients with diffuse lung diseases

Proteolytic and antiproteolytic activities were studied in bronchoalveolar lavages of 102 patients with sarcoidosis of respiratory tissues, exogenous allergic and idiopathic fibrotic alveolitis. Deficiency of the antiproteolytic activity was observed in all the impairments studied, whereas elastase-...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 34; no. 6; p. 100
Main Authors Kaminskaia, G O, Stepanian, I E, Zhukova, N L
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1988
Subjects
Adult
Bird Fancier's Lung - diagnosis
Bird Fancier's Lung - enzymology
Bronchoalveolar Lavage Fluid - enzymology
Female
Humans
Lung Diseases - diagnosis
Lung Diseases - enzymology
Male
Middle Aged
Peptide Hydrolases - analysis
Peptide Hydrolases - blood
Protease Inhibitors - analysis
Protease Inhibitors - blood
Pulmonary Fibrosis - diagnosis
Pulmonary Fibrosis - enzymology
Sarcoidosis - diagnosis
Sarcoidosis - enzymology
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Summary:Proteolytic and antiproteolytic activities were studied in bronchoalveolar lavages of 102 patients with sarcoidosis of respiratory tissues, exogenous allergic and idiopathic fibrotic alveolitis. Deficiency of the antiproteolytic activity was observed in all the impairments studied, whereas elastase-like and fibrinolytic activities were distinctly increased in sarcoidosis and exogenous allergic alveolitis. Impairments of bronchial mucose, pathogenic microflora, increase in content of neutrophils in respiratory tract as well as potential deficiency of the body inhibitory system were responsible for disbalance in the system proteinases-inhibitors of bronchoalveolar lavage. Biochemical examination of bronchoalveolar lavages enabled to find that clinico-roentgenological dynamics of these diseases correlated with the level of proteolytic activity.
ISSN:0042-8809