Synthesis, DNA binding, and cleaving properties of an ellipticine-salen.copper conjugate

The synthesis of a DNA-cutting agent that conjugates an ellipticine chromophore and a copper complex of bis(salicylidene)ethylenediamine, referred to as a salen, is reported. The presence of the salen.Cu complex allows cleavage of DNA via oxygen-based radicals, and the ellipticine moiety serves as a...

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Published inBioconjugate chemistry Vol. 8; no. 6; pp. 789 - 792
Main Authors Routier, S, Bernier, J L, Catteau, J P, Colson, P, Houssier, C, Rivalle, C, Bisagni, E, Bailly, C
Format Journal Article
LanguageEnglish
Published United States 01.11.1997
Subjects
Chelating Agents - chemistry
Chelating Agents - metabolism
Chelating Agents - pharmacology
Circular Dichroism
Copper - chemistry
Copper - metabolism
Copper - pharmacology
DNA - drug effects
DNA - metabolism
DNA Damage
Ellipticines - chemical synthesis
Ellipticines - metabolism
Ellipticines - pharmacology
Ethylenediamines - chemistry
Ethylenediamines - metabolism
Ethylenediamines - pharmacology
Organometallic Compounds - chemical synthesis
Organometallic Compounds - metabolism
Organometallic Compounds - pharmacology
Spectrophotometry
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Summary:The synthesis of a DNA-cutting agent that conjugates an ellipticine chromophore and a copper complex of bis(salicylidene)ethylenediamine, referred to as a salen, is reported. The presence of the salen.Cu complex allows cleavage of DNA via oxygen-based radicals, and the ellipticine moiety serves as a DNA anchor. Spectroscopic measurements indicate that the intercalation geometry of the ellipticine chromophore is preserved with the hybrid. The cleavage is much more efficient with the conjugate than with the Schiff base copper complex alone.
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SourceType-Scholarly Journals-1
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ISSN:1043-1802
1520-4812