Value and duration of the bone localization of gallium in the mouse

Gallium was administered subcutaneously to mice, and was found to be localized essentially in the skeleton. It was measured in the bones of animals given daily injections of gallium sulfate. There was little or no mortality. The amount of gallium found rose with the number of injections, and was gre...

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Bibliographic Details
Published inPathologie biologie (Paris) Vol. 23; no. 8; p. 605
Main Authors Maurel, E, Bouissou, P, Mazard, A M, Bouissou, H
Format Journal Article
LanguageFrench
Published France 01.10.1975
Subjects
Animals
Bone and Bones - metabolism
Dose-Response Relationship, Drug
Female
Gallium - administration & dosage
Gallium - metabolism
Gallium - toxicity
Injections, Subcutaneous
Mice
Time Factors
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Summary:Gallium was administered subcutaneously to mice, and was found to be localized essentially in the skeleton. It was measured in the bones of animals given daily injections of gallium sulfate. There was little or no mortality. The amount of gallium found rose with the number of injections, and was greater when higher doses were injected. Elimination was very low after cessation of treatment. Results were used to study the action of gallium on cutaneous allografts in mice.
ISSN:0369-8114