Cytoadherence of Plasmodium falciparum and complications of malaria

Sequestration is a phenomenon where mature Plasmodium falciparum infected-erythrocytes block microvessels. Many cells (particularly epithelial cells) can cytoadhere to these erythrocytes and this may play an important role in the physiopathology of cerebral malaria. Many in vitro models have been pr...

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Bibliographic Details
Published inDakar medical Vol. 36; no. 2; p. 192
Main Authors Trossaert, M, Dieye, A, Dieye, Y, Sarthou, J L
Format Journal Article
LanguageFrench
Published Senegal 1991
Subjects
Animals
Cell Adhesion
Endothelium, Vascular - cytology
Endothelium, Vascular - physiology
Erythrocytes - parasitology
Humans
Malaria, Cerebral - etiology
Malaria, Falciparum - complications
Plasmodium falciparum - physiology
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Summary:Sequestration is a phenomenon where mature Plasmodium falciparum infected-erythrocytes block microvessels. Many cells (particularly epithelial cells) can cytoadhere to these erythrocytes and this may play an important role in the physiopathology of cerebral malaria. Many in vitro models have been proposed. They permitted different studies about cytoadherence and clinical effects. Contradictory results have been yet published. Investigations at a molecular level of cytoadherence moiety contribute to a better understanding of physiopathology and therapeutic improvements of cerebral malaria.
ISSN:0049-1101