Comparative analysis of antiarrhythmic action and electrophysiological effects of a new benzodiazepine derivative gidazepam and ethacizin in arrhythmias of various genesis

The antiarrhythmic and electrophysiological effects of the new benzodiazepine tranquilizer gidazepam versus ethacizin were examined in patients with cardiac arrhythmias. The antiarrhythmic effect of the agent was found during 24-day monitoring and simulated psychoemotional stress in 81% of patients...

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Bibliographic Details
Published inKardiologiia Vol. 32; no. 6; p. 35
Main Authors Skibitskiĭ, V V, Petrova, T R, Kanorskiĭ, S G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.06.1992
Subjects
Adolescent
Adult
Aged
Anti-Anxiety Agents
Anti-Arrhythmia Agents - therapeutic use
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - psychology
Benzodiazepines
Benzodiazepinones - therapeutic use
Cardiac Pacing, Artificial
Electrocardiography, Ambulatory
Electrophysiology
Female
Humans
Male
Middle Aged
Moricizine - analogs & derivatives
Moricizine - therapeutic use
Psychotropic Drugs - therapeutic use
Time Factors
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Summary:The antiarrhythmic and electrophysiological effects of the new benzodiazepine tranquilizer gidazepam versus ethacizin were examined in patients with cardiac arrhythmias. The antiarrhythmic effect of the agent was found during 24-day monitoring and simulated psychoemotional stress in 81% of patients with neurocirculatory dystonia and in 61% of patients with coronary heart disease. The antiarrhythmic effects developed with gidazepam-induced changes in electrophysiological properties of the cardiac conduction system. The preventive antiarrhythmic effect of gidazepam was demonstrated to be higher than that of ethacizin during stress in patients with arrhythmias of extra-ischemic genesis.
ISSN:0022-9040