Clinical immunosorbents on a basis of polymeric matrices

Immobilization of anti-IgE on space-network polymers containing aliphatic amino- and hydrazido groups as a way of producing clinical immunosorbents has been studied. Influence of active group concentration on the specific activity of the immobilized antibodies and sorption dynamics of IgE from plasm...

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Bibliographic Details
Published inBioorganicheskaia khimiia Vol. 14; no. 11; p. 1524
Main Authors Chuchalin, A G, Gorchakov, V D, Lebedin, Iu S, Avdiushkina, T V, Sakodynskiĭ, K I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1988
Subjects
Animals
Antibodies, Anti-Idiotypic - isolation & purification
Antigen-Antibody Complex
Humans
Immunoglobulin E - immunology
Immunoglobulin E - isolation & purification
Immunosorbents
Polymers
Rabbits
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Summary:Immobilization of anti-IgE on space-network polymers containing aliphatic amino- and hydrazido groups as a way of producing clinical immunosorbents has been studied. Influence of active group concentration on the specific activity of the immobilized antibodies and sorption dynamics of IgE from plasma of patents are investigated. Immunosorbents can be sterilized by gamma-irradiation without any loss of capacity. It is shown that the immunosorbents can be reused after regeneration. Basing on the results obtained, acrylonitrile- divinylbenzene copolymer with hydrazido groups is considered as the most perspective for production of clinical immunosorbents.
ISSN:0132-3423