Disordered Na+/H+ metabolism in the erythrocytes of patients with insulin-dependent diabetes mellitus

Na+/H+ countertransport speed in red cells of insulin-dependent diabetes (IDDM) patients was studied. The rate of Na+/H+ exchange in diabetic erythrocytes did not differ statistically from the rate of such exchange in control erythrocytes. Statistically significant differences in the rates of Na+/H+...

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Bibliographic Details
Published inTerapevtic̆eskii arhiv Vol. 68; no. 2; p. 53
Main Authors Balashova, T S, Tomilova, E N, Golega, E N, Balabolkin, M I, Kubatiev, A A
Format Journal Article
LanguageRussian
Published Russia (Federation) 1996
Subjects
Adult
Biological Transport
Diabetes Mellitus, Type 1 - blood
Diabetic Angiopathies - blood
Diabetic Nephropathies - blood
Diabetic Retinopathy - blood
Erythrocytes - metabolism
Female
Humans
Hydrogen - blood
Hydrogen-Ion Concentration
Male
Sodium - blood
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Summary:Na+/H+ countertransport speed in red cells of insulin-dependent diabetes (IDDM) patients was studied. The rate of Na+/H+ exchange in diabetic erythrocytes did not differ statistically from the rate of such exchange in control erythrocytes. Statistically significant differences in the rates of Na+/H+ exchange in red cells of patients with and without angiopathies were not found either, though the above rate was higher in nephropathy patients compared to those with retinopathy. Statistically significant acceleration of the Na+/H+ exchange rate was found in red cells of patients with family history of IDDM compared to patients without hereditary predisposition. There was no correlation between the rate of Na+/H+ exchange and duration of diabetes mellitus. It is suggested that acceleration of Na+/H+ countertransport in red cells of different diabetic groups may be polyetiological.
ISSN:0040-3660