The kallikrein-kinin system of the blood and protease-protease inhibitor balance in active sarcoidosis

• Published in: Terapevtic̆eskii arhiv Vol. 60; no. 1; p. 70
• Main Authors: Kaminskaia, G O, Balta, N G, Zhukova, N L, Stepanian, I E, Lovacheva, O V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1988
• Subjects: Adult; alpha 1-Antitrypsin - metabolism; Bronchoalveolar Lavage Fluid - enzymology; Female; Humans; Kallikreins - blood; Kinins - blood; Lung Diseases - blood; Lung Diseases - metabolism; Male; Middle Aged; Sarcoidosis - blood; Sarcoidosis - metabolism; Sputum - enzymology; Trypsin - metabolism
• ISSN: 0040-3660

The status of the blood kinin system, activity of serum inhibitors of proteinases (alpha 1-protease inhibitor and alpha 2-macroglobulin) as well as indices of activity of trypsin-like proteinases, elastolytic and fibrinolytic activity, free antitryptic activity and complete content of acid stable inhibitors were studied in the morning sputum and bronchoalveolar washesoff of 62 patients with intrathoracic sarcoidosis. It was shown that in active sarcoidosis proteinase-inhibitors balance got disturbed as a result of a decrease in the activity of serum inhibitors, suppression of local secretion of acid stable inhibitors and inactivation at the level of alpha 1-protease inhibitor alveoles. Excessive activation of the kinin system was noted in the blood flow and elevation of all types of proteolytic activity in the respiratory system. It was assumed that the above changes reflected disturbed self-control processes in the body and caused progression of disease and pneumofibrosis formation.