Diabetes mellitus and changes in hemostasis: study of the fibrinolytic response of insulin-dependent patients without vascular disease

Diabetes mellitus (DM) is characterized by a hypercoagulability state and many of these disorders are corrected with adequate metabolic control. The goal of this study was to assess diverse hemostatic and fibrinolytic parameters in 12 insulin-dependent (IDDM) metabolically controlled patients withou...

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Bibliographic Details
Published inRevista clínica espanõla Vol. 184; no. 3; p. 128
Main Authors García Pérez, A A, Marco Vera, P, Mompel Sanjuan, A, Abad Gosalbez, A
Format Journal Article
LanguageSpanish
Published Spain 01.02.1989
Subjects
Adolescent
Adult
Diabetes Mellitus, Type 1 - blood
Exercise Test
Fibrinolysis
Hemostasis
Humans
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Summary:Diabetes mellitus (DM) is characterized by a hypercoagulability state and many of these disorders are corrected with adequate metabolic control. The goal of this study was to assess diverse hemostatic and fibrinolytic parameters in 12 insulin-dependent (IDDM) metabolically controlled patients without vascular lesions and in a group of 12 healthy volunteers. A significant difference was observed in the euglobulin lysis time (ELT), after a stress test, since only 3 patients had an adequate fibrinolytic response. These results suggest that the fibrinolytic alterations found in DM are not secondary to metabolic disorders caused by the disease and we can consider that the existence of subclinical alterations of the vascular endothelium would be responsible for these alterations.
ISSN:0014-2565