Effect of scopolamine on temporary connection formation and fixation in rats with altered brain noradrenaline content

The locus coeruleus was ablated in rats or a 100 mg/kg dose of disulfiram and a 0.5 mg/kg dose of scopolamine were administered to them. Then a conditioned two-side avoidance reflex was elaborated. The locus coeruleus ablation and administration of disulfiram brought about a nearly equal reduction o...

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Bibliographic Details
Published inZurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 31; no. 3; p. 571
Main Author Orlova, N V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1981
Subjects
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
Brain Chemistry
Conditioning, Classical - drug effects
Disulfiram - pharmacology
Locus Coeruleus - physiology
Male
Norepinephrine - analysis
Norepinephrine - physiology
Rats
Scopolamine Hydrobromide - pharmacology
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Summary:The locus coeruleus was ablated in rats or a 100 mg/kg dose of disulfiram and a 0.5 mg/kg dose of scopolamine were administered to them. Then a conditioned two-side avoidance reflex was elaborated. The locus coeruleus ablation and administration of disulfiram brought about a nearly equal reduction of noradrenaline (NA) content in the brain. Scopolamine against the background of a low NA level did not change its content. Ablation of locus coeruleus, administration of disulfiram and scopolamine did not prevent the elaboration, fixation and retention of the conditioned defensive reflex. Scopolamine introduced to animal with ablated locus coeruleus while not affecting the elaboration of defensive conditioned two-side avoidance reflex, completely prevented its retention. Administration of scopolamine to animals with a depressed NA synthesis produced a less profound amnesia.
ISSN:0044-4677