Radioprotective effect of drug combinations on the small intestine

The study of the radioprotective effect of complexes containing small amounts of cystamine or gammaphos mixed with mexamine, gutimine and ethyrone on mouse small intestine showed high efficiency of the drugs as determined by cellularity and DNA-synthesizing activity of intestinal epithelium. This is...

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Bibliographic Details
Published inRadiobiologiia Vol. 26; no. 3; p. 402
Main Authors Vladimirov, V G, Konovalova, L I, Tarnopol'skaia, L G
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1986
Subjects
Animals
Cell Count
Cystamine - metabolism
DNA - biosynthesis
DNA - radiation effects
Drug Therapy, Combination
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Intestinal Mucosa - pathology
Intestinal Mucosa - radiation effects
Intestine, Small - drug effects
Intestine, Small - metabolism
Intestine, Small - pathology
Intestine, Small - radiation effects
Male
Mice
Mice, Inbred Strains
Radiation Injuries, Experimental - metabolism
Radiation Injuries, Experimental - pathology
Radiation Injuries, Experimental - prevention & control
Radiation-Protective Agents - administration & dosage
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Summary:The study of the radioprotective effect of complexes containing small amounts of cystamine or gammaphos mixed with mexamine, gutimine and ethyrone on mouse small intestine showed high efficiency of the drugs as determined by cellularity and DNA-synthesizing activity of intestinal epithelium. This is connected with the influence of the complex mexamine + gutimine + ethyrone on the pharmacodynamics and pharmacokinetics of cystamine and gammaphos.
ISSN:0033-8192