Use of liquid sorbents based on chitosan for treatment of diffuse forms of peritonitis

Chitosan-based gelatinous affinity sorbent containing 9 mg/ml of polymyxin B was injected into the infected peritoneal cavity for twenty-four hours for detoxification in diffuse peritonitis. The clinical assay of blood plasma (Spectrum Abbot, USA) revealed that the lavage of the infected abdomen by...

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Bibliographic Details
Published inPatologicheskaia fiziologiia i eksperimental'naia terapiia no. 3; p. 49
Main Authors Bol'shakov, I N, Nasibov, S M, Kulaev, D V, Lopukhin, Iu M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1994
Subjects
Animals
Chitin - analogs & derivatives
Chitin - therapeutic use
Chitosan
Peritonitis - drug therapy
Polymyxin B - therapeutic use
Rats
Rats, Wistar
Sorption Detoxification - methods
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Summary:Chitosan-based gelatinous affinity sorbent containing 9 mg/ml of polymyxin B was injected into the infected peritoneal cavity for twenty-four hours for detoxification in diffuse peritonitis. The clinical assay of blood plasma (Spectrum Abbot, USA) revealed that the lavage of the infected abdomen by polymyxin B-containing adsorbent resulted in systemic detoxification. The effect was associated with normalization of direct bilirubin, cholesterol, and triglyceride levels, a 4-fold decrease in uric acid levels, and a 34-fold increase in alkaline phosphatase activity, and a greater than 70-fold enhancement of hepatic aspartate aminotransferase activity.
ISSN:0031-2991