Primary pathological changes in cells infected with tick-borne encephalitis virus

Synthesis and the content of RNA and protein in cells of the pig embryo kidneys infected with tick--borne encephalitis virus were studied by means of autoradiography and cytophotometry. Acceleration of synthesis and accumulation of RNA (in cellular structures) were estimated as over 125--200% of the...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 17; no. 1; p. 84
Main Authors Erman, B A, Pashnina, N Ia, Subbotina, L S, Tkhorzhevskií, V V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1975
Subjects
Animals
Autoradiography
Cell Line
Cell Nucleolus - metabolism
Cell Nucleus - metabolism
Cytopathogenic Effect, Viral
Cytoplasm - metabolism
Encephalitis Viruses, Tick-Borne - growth & development
Kidney - embryology
Protein Biosynthesis
RNA - biosynthesis
Swine
Tritium
Uridine
Virus Replication
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Summary:Synthesis and the content of RNA and protein in cells of the pig embryo kidneys infected with tick--borne encephalitis virus were studied by means of autoradiography and cytophotometry. Acceleration of synthesis and accumulation of RNA (in cellular structures) were estimated as over 125--200% of the initial level followed by a decrease in 12 hr when the virus release from the cells occurred. By the 2nd and 6--8th hr of infection (in the period of synthesis of early and late virus material), two peaks of protein contents over 123--131% were observed. The RNA and protein shifts are well correlated with the virus reproduction stages.
ISSN:0041-3771