The functional and morphological changes in the liver and kidneys of white rats treated with aluminum

A total of 126 white male Wistar rats under subacute conditions were studied. Of them, 76 were perorally treated with AlCl3 in a dose of 3 mg/kg b.w. daily for 40 days. Activities of acid phosphatase (AP), succinate dehydrogenase (SDH), adenosine triphosphatase (ATP-ase) and the contents of glycogen...

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Published inEksperimentalna meditsina i morfologiia Vol. 32; no. 1-2; p. 52
Main Authors Nikolova, P, Softova, E, Kavaldzhieva, B, Boiadzhieva, S
Format Journal Article
LanguageBulgarian
Published Bulgaria 1994
Subjects
Administration, Oral
Aluminum Compounds - administration & dosage
Aluminum Compounds - toxicity
Animals
Chlorides - administration & dosage
Chlorides - toxicity
Histocytochemistry
Kidney - drug effects
Kidney - enzymology
Kidney - pathology
Liver - drug effects
Liver - enzymology
Liver - pathology
Male
Rats
Time Factors
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Summary:A total of 126 white male Wistar rats under subacute conditions were studied. Of them, 76 were perorally treated with AlCl3 in a dose of 3 mg/kg b.w. daily for 40 days. Activities of acid phosphatase (AP), succinate dehydrogenase (SDH), adenosine triphosphatase (ATP-ase) and the contents of glycogen, glucoproteins and RNA were dynamically followed-up in the liver and kidney. Serum activities of ASAT and ALAT were estimated by Borhringer's tests. Morphological changes were histochemically investigated. There was an initial elevation followed by reduction mostly manifested for SDH and ATP-ase and an increase of AP at the end of trial. Histochemical data argued for disorders of protein and carbohydrate metabolism. Morphological alterations more outlined in the liver became more severe until the end of the experiment.
ISSN:0367-0643