Combined effects of interferon alpha-A/D with fluoropyrimidine derivatives in the subrenal capsule assay

• Published in: Gan to kagaku ryoho Vol. 15; no. 8; p. 2285
• Main Authors: Nishiyama, M, Takagami, S, Kirihara, Y, Saeki, T, Niimi, K, Kim, R, Jinushi, K, Toge, T, Niimoto, M, Hattori, T
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.08.1988
• Subjects: Animals; Colonic Neoplasms - pathology; Drug Synergism; Fluorouracil - administration & dosage; Fluorouracil - pharmacology; Interferon Type I - administration & dosage; Interferon Type I - pharmacology; Male; Mice; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms - pathology; Subrenal Capsule Assay; Tegafur - administration & dosage; Tegafur - pharmacology
• ISSN: 0385-0684

The combined effects of interferon alpha-A/D (IFN alpha-A/D) with 5-fluorouracil and fluoropyrimidine derivatives such as 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur), UFT, 1-hexylcarbamoyl-5-fluorouracil (HCFU) and 5'-deoxy-5-fluorouracil (5'-DFUR), were examined by 4-day subrenal capsule assay. Four human tumor xenografts serially transplanted in athymic mice, H-111, SH-10 established from gastric cancers, CH-4 and CH-5 from colon cancers, were used. In this experiment, the adequate dose of each agent was estimated as 50 mg/kg for 5-FU, 473 mg/kg for tegafur, 433 mg/kg for UFT, 50 mg/kg for HCFU, 185 mg/kg for 5'-DFUR and 1 x 10(5) IU for IFN alpha-A/D, respectively. When synergistic, additive and subadditive effects were defined as positive combined effects, all combinations produced positive combined effects against H-111 and CH-5, while negative ones were observed for all combinations against CH-4. The combinations of 5-FU, HCFU and 5'-DFUR with IFN alpha-A/D produced synergistic effects against SH-10. These results indicate that the combination therapy of 5-FU and fluoropyrimidine derivatives with IFN alpha-A/D would be useful.