The interaction of the renin-angiotensin and enkephalinergic systems of the brain and hypophysis in normal rats and in experimental pathology of the hypothalamo-hypophyseal-adrenal complex

Administration of angiotensin-converting enzyme inhibitor captopril inhibited the activity of renin-angiotensin system (RAS), increased leukin-enkephalin level in the hypothalamus and adenohypophysis. The data obtained suggest that the enzyme is an important link in the mechanism of interaction betw...

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Bibliographic Details
Published inFiziologicheskii zhurnal imeni I.M. Sechenova Vol. 82; no. 4; p. 60
Main Authors Kalinskaia, L N, Kononenko, V Ia
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.04.1996
Subjects
Adrenalectomy
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Brain - drug effects
Brain - physiology
Brain Chemistry - drug effects
Brain Chemistry - physiology
Captopril - pharmacology
Enkephalin, Leucine - analysis
Enkephalin, Leucine - drug effects
Enkephalin, Leucine-2-Alanine - analogs & derivatives
Enkephalin, Leucine-2-Alanine - pharmacology
Hypothalamo-Hypophyseal System - drug effects
Hypothalamo-Hypophyseal System - physiology
Male
Pituitary Gland - drug effects
Pituitary Gland - physiology
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - physiology
Rats
Rats, Wistar
Receptors, Opioid - drug effects
Receptors, Opioid - physiology
Renin-Angiotensin System - drug effects
Renin-Angiotensin System - physiology
Time Factors
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Summary:Administration of angiotensin-converting enzyme inhibitor captopril inhibited the activity of renin-angiotensin system (RAS), increased leukin-enkephalin level in the hypothalamus and adenohypophysis. The data obtained suggest that the enzyme is an important link in the mechanism of interaction between the renin-angiotensin and enkephalinergic systems in rats.
ISSN:1027-3646