Blocking of carbohydrate adhesion. A new principle for therapy of many conditions?

Cell adhesion is of fundamental biological importance. In this article we describe the therapeutic potential of blocking carbohydrate dependent adhesion. The animal studies are promising, and there is a realistic hope that "anti-adhesion" therapy for acute conditions like reperfusion injur...

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Bibliographic Details
Published inTidsskrift for den Norske Lægeforening Vol. 115; no. 16; p. 1957
Main Authors Bryne, M, Asheim, H C, Giercksky, K E
Format Journal Article
LanguageNorwegian
Published Norway 20.06.1995
Subjects
Animals
Bacterial Infections - drug therapy
Carbohydrates - chemistry
Carbohydrates - physiology
Cell Adhesion - drug effects
Cell Adhesion Molecules
Humans
Neoplasms - drug therapy
Neoplasms - physiopathology
Reperfusion Injury - drug therapy
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Summary:Cell adhesion is of fundamental biological importance. In this article we describe the therapeutic potential of blocking carbohydrate dependent adhesion. The animal studies are promising, and there is a realistic hope that "anti-adhesion" therapy for acute conditions like reperfusion injury and severe infections will be of clinical value. Treatment of more chronic diseases like rheumatoid arthritis and cancer by blocking carbohydrate mediated cell adhesion is theoretically possible, but probably more difficult.
ISSN:0029-2001