Immuno-stimulating effect of levamisole in the immunization of guinea pigs vaccinated against brucellosis

The immuno-stimulating Levamisole action was checked by the authors in guinea-pigs vaccinated against brucellosis and exposed to the challenge test afterwards against 2.308 Brucella abortus pathogenic strain. Twelve lots of eight guinea-pigs were used disposed in the following distribution: Lots I,...

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Bibliographic Details
Published inArquivos do Instituto Biológico (São Paulo) Vol. 45; no. 4; p. 313
Main Authors Sandoval, L A, Giorgi, W, Amaral, L B, Zampolli, E, Manzati, M T
Format Journal Article
LanguagePortuguese
Published Brazil 01.10.1978
Subjects
Animals
Antibody Formation - drug effects
Brucella Vaccine - administration & dosage
Brucellosis - immunology
Guinea Pigs
Levamisole - immunology
Levamisole - pharmacology
Tetramisole - immunology
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Summary:The immuno-stimulating Levamisole action was checked by the authors in guinea-pigs vaccinated against brucellosis and exposed to the challenge test afterwards against 2.308 Brucella abortus pathogenic strain. Twelve lots of eight guinea-pigs were used disposed in the following distribution: Lots I, III, IV were vaccinated with B-19 strain vaccine; lots II, IV and VI were vaccinated with the same vaccine and, after 48 hours, received the Levamisole injection. Lots VII VIII received only the Levamisole injection and the pathogenic Brucella strain, forming the control groups. The vaccinated guinea-pigs showed a higher protection against challenge, always above 75% in relation to the lots that were only vaccinated, demonstrating a dear immuno-stimulating action of the essayed product. Considering the obtained results in this assay, the authors speculate on the anti-brucellosis vaccines potentialization with immuno-stimulating products, as Levamisole.
ISSN:0020-3653