Study of cell surface antigens induced by herpes simplex virus. Note II. Some properties of the antigens

Surface antigens induced by herpes simplex virus infection in HeLa cells remain unaltered after treatment of the cells with 2% formalin for 10 min or with 0.08% trypsin for 15 min at 37 degrees C. A longer trypsin treatment (for 1 hour) will cause gradual alterations in the virus-induced antigens. H...

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Bibliographic Details
Published inVirologie Vol. 30; no. 3; p. 179
Main Authors Ghyka, G R, Muţiu, A, Cajal, N
Format Journal Article
LanguageEnglish
Published Romania 01.07.1979
Subjects
Antigens, Surface - analysis
Antigens, Viral - analysis
Formaldehyde - pharmacology
HeLa Cells
Simplexvirus - immunology
Staphylococcus
Trypsin - pharmacology
Virus Cultivation
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Summary:Surface antigens induced by herpes simplex virus infection in HeLa cells remain unaltered after treatment of the cells with 2% formalin for 10 min or with 0.08% trypsin for 15 min at 37 degrees C. A longer trypsin treatment (for 1 hour) will cause gradual alterations in the virus-induced antigens. Hence, these antigens are proteins deeply implanted within the cellular membrane. Their mobility--optimal at 37 degrees C--allows aggregation of the antigens in the form of caps or patches by polyvalent ligands such as IgG.
ISSN:0253-181X