Metabolism of 7,12-dimethylbenz(alpha)anthracene in vivo

The metabolism of 7,12-dimethylbenz(alpha) anthracene (DMBA) was studied, using labelled DMBA-H3, after intravenous injection of the carcinogen in female animals. The maximum excretion of the metabolites took place during the period ranging from 6 to 24 hours. The content of liposoluble metabolites...

Full description

Saved in:
Bibliographic Details
Published inVoprosy onkologij Vol. 22; no. 9; p. 54
Main Authors Semin, B K, Esakova, T D, Petrusevich, Iu M, Tarusov, B N
Format Journal Article
LanguageRussian
Published Russia (Federation) 1976
Subjects
9,10-Dimethyl-1,2-benzanthracene - analysis
9,10-Dimethyl-1,2-benzanthracene - metabolism
9,10-Dimethyl-1,2-benzanthracene - urine
Animals
Benz(a)Anthracenes - metabolism
Feces - analysis
Female
Injections, Intravenous
Rats
Online AccessGet more information

Cover

More Information
Summary:The metabolism of 7,12-dimethylbenz(alpha) anthracene (DMBA) was studied, using labelled DMBA-H3, after intravenous injection of the carcinogen in female animals. The maximum excretion of the metabolites took place during the period ranging from 6 to 24 hours. The content of liposoluble metabolites in the urine was insignificant (about 6%), whereas in feces it was much higher (about 40%). Among the metabolites in feces the content of DMBA, 12-hydroxymethyl-7-methylbenz(alpha)anthracene and unidentified DMBA metabolite was significantly high. The content of 7-hydroxymethyl-12-methylbenz(alpha) anthracene fails to show any significant level.
ISSN:0507-3758