Characteristics of the pharmacological action of piracetam

As concerns most generally accepted characteristics adopted in pharmacological studies of psychotropic drugs pyracetam is little active, has no effect on the EEG of the cortex and subcortical structures of the brain. At the same time, in a number of tests this drug displayed a well-marked influence...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 40; no. 6; p. 676
Main Authors Mashkovskiĭ, M D, Roshchina, L F, Polezhaeva, A I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1977
Subjects
Animals
Barbiturates - pharmacology
Behavior, Animal - drug effects
Brain - drug effects
Brain - physiology
Cats
Conditioning, Classical - drug effects
Drug Interactions
Electroencephalography
Electrophysiology
Escape Reaction - drug effects
Male
Penicillins - pharmacology
Piracetam - pharmacology
Pyrrolidinones - pharmacology
Rabbits
Rats
Seizures - chemically induced
Strychnine - pharmacology
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Summary:As concerns most generally accepted characteristics adopted in pharmacological studies of psychotropic drugs pyracetam is little active, has no effect on the EEG of the cortex and subcortical structures of the brain. At the same time, in a number of tests this drug displayed a well-marked influence on the central nervous system. It restrains convulsive activity provoked by application to the cerebral cortex of strychnine and penicillin solutions, reduces EEG disturbances produced by barbiturates poisoning and acute hypoxia of the brain. Pyracetam also facilitates the process of teaching in rats, improves the execution of a developed conditioned avoidance reaction, protects rats against manifestations of retrograde amnesia induced by an electric shock, applied after development of the conditioned reflex of passive avoidance.
ISSN:0014-8318