Combination of novoimanine with antibiotics with a different mechanism of action

Ampicillin, kanamycin, fusidic acid and rifocin significantly increased the effect of novoimanin on Staph. aureus 209. Histon F1 and spectinomycin did not influence the effect of novoimanin. Inefficiency of novoimanin combination with histon F1 provided a supposition that their effect may be directe...

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Bibliographic Details
Published inAntibiotiki Vol. 20; no. 7; p. 636
Main Authors Avenirova, E L, Ashmarin, I P, Movchan, N A, Lapina, I K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.06.1975
Subjects
Ampicillin - pharmacology
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents, Local - pharmacology
Cell Division - drug effects
Drug Interactions
Drug Synergism
Fusidic Acid - pharmacology
Histones - pharmacology
Kanamycin - pharmacology
Plant Extracts - pharmacology
Plants, Medicinal
Rifampin - pharmacology
Spectinomycin - pharmacology
Staphylococcus aureus - drug effects
Staphylococcus aureus - ultrastructure
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Summary:Ampicillin, kanamycin, fusidic acid and rifocin significantly increased the effect of novoimanin on Staph. aureus 209. Histon F1 and spectinomycin did not influence the effect of novoimanin. Inefficiency of novoimanin combination with histon F1 provided a supposition that their effect may be directed to the same cell structures and most probably to the membranes. This was confirmed by the data of electron microscopy. The most effective combinations were recommended for the studies on their possible clinical use.
ISSN:0003-5637