Biogenic amines in the epiphysis and hypothalamus under normal conditions and following ovariectomy

Melatonin content in the epiphysis, serotonin, noradrenaline, dopamine-in the hypothalamus, gonadotropins--in the hypophysis of rats was studied under normal conditions and following ovariectomy; regularly of the estral cycle phases was studied as well. Two series of experiments were conducted on 12...

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Bibliographic Details
Published inProblemy ėndokrinologii Vol. 23; no. 4; p. 68
Main Authors Grishchenko, V I, Koliada, L D, Demidenko, D I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1977
Subjects
Animals
Biogenic Amines - analysis
Castration
Dopamine - analysis
Estrus
Female
Gonadotropins, Pituitary - analysis
Hypothalamus - analysis
Melatonin - analysis
Norepinephrine - analysis
Pineal Gland - analysis
Pituitary Gland - analysis
Pregnancy
Rats
Serotonin - analysis
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Summary:Melatonin content in the epiphysis, serotonin, noradrenaline, dopamine-in the hypothalamus, gonadotropins--in the hypophysis of rats was studied under normal conditions and following ovariectomy; regularly of the estral cycle phases was studied as well. Two series of experiments were conducted on 120 rats with regular estral cycles. The animals were divided into groups according to the estral cycle phase. Melatonin concentration in the epiphysis, serotonin, noradrenaline, dopamine--in the hypothalamus was subject to variations coinciding with the estral cycle phases. Serotonin, noradrenaline, and dopamine content decreased in the hypophysis of ovariectomized rats in comparison with control; melatonin content rose in the epiphysis. There was no complete extinction of the estral cycle in the course of investigation (20 days). The action of castration on the sexual cycle depended on the phase at which the rats were subjected to ovariectomy. A reverse relationship existed between the melatonin content in the epiphysis and serotonin content in the hypothalamus, this serving as one of the important factors in the regulation of the sexual function.
ISSN:0375-9660