Cytotoxic action of Pseudomonas aeruginosa hemolysin

The cytopathic action of haemolysin of Pseudomonas aeruginosa has been studied in mouse and human leucocytes. The morphological changes suggest that haemolysin affects the molecular architecture of the cell membrane, whose permeability is increased. It does not induce non-specific stimulation of per...

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Bibliographic Details
Published inComptes rendus des seances de la Societe de biologie et de ses filiales Vol. 173; no. 1; p. 51
Main Authors Borderon, E, Reinert, P, Calamy, G
Format Journal Article
LanguageFrench
Published France 1979
Subjects
Animals
Bacterial Toxins - antagonists & inhibitors
Bacterial Toxins - pharmacology
Cell Membrane Permeability - drug effects
Hemolysin Proteins - antagonists & inhibitors
Humans
Leukocytes - cytology
Leukocytes - drug effects
Lymphocytes - drug effects
Mice
Neutrophils - cytology
Neutrophils - drug effects
Oxygen Consumption - drug effects
Phagocytosis - drug effects
Pseudomonas aeruginosa
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Summary:The cytopathic action of haemolysin of Pseudomonas aeruginosa has been studied in mouse and human leucocytes. The morphological changes suggest that haemolysin affects the molecular architecture of the cell membrane, whose permeability is increased. It does not induce non-specific stimulation of peripheral lymphocytes. Normal sera and albumin neutralize the hemolytic activity of haemolysin; this inhibition is also observed, to a les extent, on the lytic action on leucocytes. This raises the possibility that the two activities are probably associated with the same molecule.
ISSN:0037-9026