Determination of intra-uterine oxygen tension in rats after biovariectomy between the 7th and 12th day of gestation

In pregnant female rat, oxygen tension was measured in vivo with an oxygen microelectrode and the following statistically significant data (Student's test) were obtained: -- not significant variability in four groups of six control rats; -- highly significant decrease of oxygen tension twenty-f...

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Bibliographic Details
Published inAnnales d'endocrinologie Vol. 38; no. 3; p. 195
Main Author Clabaut, M
Format Journal Article
LanguageFrench
Published France 01.05.1977
Subjects
Animals
Castration
Female
Oxygen - blood
Partial Pressure
Pregnancy
Pregnancy, Animal
Rats
Uterus - blood supply
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Summary:In pregnant female rat, oxygen tension was measured in vivo with an oxygen microelectrode and the following statistically significant data (Student's test) were obtained: -- not significant variability in four groups of six control rats; -- highly significant decrease of oxygen tension twenty-four hours after biovariectomy in four groups of six operated rats; -- in twelve operated and treated by substitutive hormonotherapy rats, pO2 was at the same level than in control rats; -- in eighteen operated rats, the oxygen tension measured after embryonic death was identical to control rats. These experiments clearly demonstrate twenty four hours after biovariectomy a decreased oxygen tension. Simultaneously to this decrease, a diminution of uterine blood flow takes place. This pO2 diminution should be dependent on decrease of ovarian hormones since the substitutive hormonotherapy prevents its appearance. A good explanation of this phenomenon is the high requirement of hypoxic embryo for oxygen; moreover after the embryonic death, the intra-uterine pO2 increases.
ISSN:0003-4266