Effectiveness of hypoxic hypoxia as a means of protecting the body from ionizing radiation exposure with the use of sodium oxybutyrate and mexamine

While exerting a pronounced antihypoxic action on the body of white mice under nypoxic hypoxia, a combination of sodium hydroxybutyrate and mexamine given in comparatively low doses (100 and 2.5 mg/kg, respectively) did not remove the radioprotective effect of hypoxic hypoxia. In hemic and histotoxi...

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Bibliographic Details
Published inFarmakologiia i toksikologiia Vol. 42; no. 5; p. 550
Main Author Bykov, N P
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1979
Subjects
5-Methoxytryptamine - therapeutic use
Animals
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Drug Therapy, Combination
Hydroxybutyrates - therapeutic use
Hypoxia - drug therapy
Male
Mice
Radiation Injuries, Experimental - therapy
Radiation Tolerance
Radiation-Protective Agents
Sodium Oxybate - therapeutic use
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Summary:While exerting a pronounced antihypoxic action on the body of white mice under nypoxic hypoxia, a combination of sodium hydroxybutyrate and mexamine given in comparatively low doses (100 and 2.5 mg/kg, respectively) did not remove the radioprotective effect of hypoxic hypoxia. In hemic and histotoxic hypoxia the drugs did not exhibit any antihy-oxic action.
ISSN:0014-8318