The effects of the relA gene on the synthesis of aminoacyl-tRNA synthetases and other transcription and translation proteins in Escherichia coli A

The effects of a partial restriction of valyl-tRNA aminoacylation on the synthesis of aminoacyl-tRNA synthetases, ribosomal proteins, and other translation and transcription proteins were examined in otherwise isogenic stringent (relA+) and relaxed (relA1) derivatives of E. coli B. The synthesis of...

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Bibliographic Details
Published inMolecular & general genetics Vol. 149; no. 3; p. 291
Main Authors Blumenthal, R M, Lemaux, P G, Neidhardt, F C, Dennis, P P
Format Journal Article
LanguageEnglish
Published Germany 22.12.1976
Subjects
Amino Acyl-tRNA Synthetases - metabolism
Escherichia coli - metabolism
Genes
Mutation
Peptide Elongation Factors
Protein Biosynthesis
Ribosomal Proteins - biosynthesis
Species Specificity
Temperature
Transcription, Genetic
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Summary:The effects of a partial restriction of valyl-tRNA aminoacylation on the synthesis of aminoacyl-tRNA synthetases, ribosomal proteins, and other translation and transcription proteins were examined in otherwise isogenic stringent (relA+) and relaxed (relA1) derivatives of E. coli B. The synthesis of individual ribosomal proteins, elongation factor G, and to a lesser extent elongation factors Tu and Ts, and the valyl- and arginyl-tRNA synthetases was found to be subject to the influence of the stringent control system. The synthesis of the alpha and beta subunits of RNA polymerase and several of the aminoacyl-tRNA synthetases, in contrast, is either not subject to the influence of the stringent control system, or is subject to additional regulatory constraints.
ISSN:0026-8925
DOI:10.1007/BF00268530