Typhoid bacilli resistant to chloramphenicol and multiresistant to antibiotics isolated at the beginning of 1971

The sensitivity of chloramphenicol (C) of 286 S. typhi strains, isolated during the last 15 years in Moldavia, was tested. The minimum inhibitory concentration (MIC) of C with regard to most of the strains ranged between 1.5 and 3 mcg/ml. The following stains were identified: strain W isolated from...

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Bibliographic Details
Published inRevista de igiena, bacteriologie, virusologie, parazitologie, epidemiologie, pneumoftiziologie. Bacteriologia, virusologia, parazitologia, epidemiologia Vol. 21; no. 4; p. 227
Main Authors Duca, E, Buiuc, D, Bercovici, C, Iosub, C
Format Journal Article
LanguageRomanian
Published Romania 01.10.1976
Subjects
Anti-Bacterial Agents - pharmacology
Chloramphenicol - pharmacology
Drug Resistance, Microbial
Salmonella typhi - drug effects
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Summary:The sensitivity of chloramphenicol (C) of 286 S. typhi strains, isolated during the last 15 years in Moldavia, was tested. The minimum inhibitory concentration (MIC) of C with regard to most of the strains ranged between 1.5 and 3 mcg/ml. The following stains were identified: strain W isolated from the feces of a carrier in 1971, with a ACKSSuT-Cl2Hg resistance spectrum transferable to E. coli K12(MIC of C less than or equal to 200 mcg/ml), 2 strains (phage type A and C1, isolated from patients, one from the feces in 1972 and the other haemoculture in 1973) with a non-transferable CSu resistance spectrum (MIC of C less than or equal to 6 and less than or equal 12 mcg/ml respectively), and 18 strains (13 phage type D9, 3 phage type Ci and 2 phage type A), isolated from 3 epidemic foci, which proved to contain variants selectable in vitro by C (MIC up to 50 mcg/ml). The resistance spectrum of the variants was not CSU transferable. Conclusions are drawn concerning the necessity of a restricted utilization of chloramphenicol.
ISSN:0376-4494