Physicochemical aspects of the mechanism of the mineralization of epiphyseal cartilage in enchondral osteogenesis

Mechanism of epiphysial cartliage mineralization is considered in terms of ion exchange concepts. Chondroitin-sulfate of matrix, which is a polyelectrolyte, served as a donor od calcium ions. Pericellular zone of matrix is considered as a semipermeable membrane. The energetic basis of the process is...

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Bibliographic Details
Published inVoprosy meditsinskoi khimii Vol. 25; no. 3; p. 297
Main Authors Peschanskiĭ, V S, Libinson, G S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.05.1979
Subjects
Bone Matrix - metabolism
Calcium Chloride - metabolism
Cartilage - metabolism
Chemical Phenomena
Chemistry, Physical
Chondroitin Sulfates - metabolism
Dose-Response Relationship, Drug
Epiphyses - metabolism
Ion Exchange
Models, Biological
Osteogenesis
Sodium Chloride - metabolism
Solutions
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Summary:Mechanism of epiphysial cartliage mineralization is considered in terms of ion exchange concepts. Chondroitin-sulfate of matrix, which is a polyelectrolyte, served as a donor od calcium ions. Pericellular zone of matrix is considered as a semipermeable membrane. The energetic basis of the process is provided by interacellular glycogenolysis in chondrocytes, entering the zone of mineralization. High concentration of glucose in lacunas of chondrocytes led to osmotic transport of water from matrix to lacunas, causing an increase in concentration of ions in free volume of the matrix. Due to ion exchange release of calcium ions occurred from the phase of polyelectrolyte into the free volume, where the state of saturation was achieved and dicalcium phosphate CaHPO4 was precipitated. Stereologic studies of epiphysial cartilage, simulation experiments and calculations corroborate the mechanism of mineralization advanced.
ISSN:0042-8809