Virus induced diabetes and the immune system. II -- Evidence for an immune pathogenesis of the acute phase of diabetes

The infection of normal DBA2 and BALB/C nu/ + mice with 2 X 10(2,6) TCID50 of the M variant of the EMC virus induced pathological mean glucose values of 426 +/- 99 mg/100 ml in DBA2 mice and 292 +/- 130 mg/100 ml in BALB/C nu/ + mice on day five following infection. As diabetic animals died afterwar...

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Published inBiomedicine / [publiee pour l'A.A.I.C.I.G.] Vol. 31; no. 1; p. 1
Main Authors Jansen, F K, Thurneyssen, O, Müntefering, H
Format Journal Article
LanguageEnglish
Published France 01.02.1979
Subjects
Animals
Diabetes Mellitus, Experimental - etiology
Diabetes Mellitus, Experimental - immunology
Encephalomyocarditis virus
Enterovirus Infections
Male
Mice
Mice, Inbred Strains
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Summary:The infection of normal DBA2 and BALB/C nu/ + mice with 2 X 10(2,6) TCID50 of the M variant of the EMC virus induced pathological mean glucose values of 426 +/- 99 mg/100 ml in DBA2 mice and 292 +/- 130 mg/100 ml in BALB/C nu/ + mice on day five following infection. As diabetic animals died afterwards, mean glucose values decreased in the surviving animals on day seven and fourteen. The infected immunodeficient BALB/C nu/nu mice with thymus aplasia did not show abnormal mean glucose values or higher standard deviation of the means (114 +/- 37 mg/100 ml) when compared to uninfected controls (117 +/- 23 mg/100 ml). This demonstrates that a complete thymus-dependent immune system seems to be necessary for the development of the acute stage of virus-induced diabetes in the mouse.
ISSN:0300-0893