Intramuscular injections and activity of serum creatine phosphokinase. Histopathological study in animal experiments

In healthy Labrador dogs a single intramuscular injection of benzoctamin, diazepam and pethidin leads to a distinct increase in serum-creatine-phosphokinase (SCK) activity, whilst a single intramuscular injection of physiologic saline has no effect whatsoever. Intravenous injection of an identical d...

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Bibliographic Details
Published inSchweizerische medizinische Wochenschrift Vol. 107; no. 27; p. 948
Main Authors Gloor, H O, Vorburger, C, Schädelin, J
Format Journal Article
LanguageGerman
Published Switzerland 09.07.1977
Subjects
Animals
Anthracenes - administration & dosage
Anthracenes - pharmacology
Creatine Kinase - blood
Diazepam - administration & dosage
Diazepam - pharmacology
Dogs
Humans
Injections, Intramuscular
Meperidine - administration & dosage
Meperidine - pharmacology
Muscles - cytology
Myocardium - cytology
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Summary:In healthy Labrador dogs a single intramuscular injection of benzoctamin, diazepam and pethidin leads to a distinct increase in serum-creatine-phosphokinase (SCK) activity, whilst a single intramuscular injection of physiologic saline has no effect whatsoever. Intravenous injection of an identical dose of the above-mentioned drugs leaves SCK activity unchanged. Muscle specimens of the injection site, excised 5 days after intramuscular injection of the same drugs, display muscle cell necrosis, macrophage proliferation and reparative changes. The impressive histological alterations point to the striated muscle cell as a probable source of the increase in SCK activity (MM fraction).
ISSN:0036-7672