Surgical shock. Acute hypocatecholaminemia and therapeutic indications of an adrenocortical vasopressor sympathicolytic drug mixture. Clinical studies and experimental research

• Published in: Revista de chirurgie, oncologie, radiologie, o.r.l., oftalmologie, stomatologie. Chirurgie Vol. 27; no. 1; p. 59
• Main Authors: Mandache, F, Prodescu, V, Mateescu, D, Giuroiu, V, Creţulescu, G, Kover, G, Abramescu, N, Gherghuţ, A, Ky, P, Oprescu, S, Ciopală, E, Stănculescu, D
• Format: Journal Article
• Language: Romanian
• Published: Romania 01.01.1979
• Subjects: Acute Kidney Injury - etiology; Animals; Catecholamines - blood; Catecholamines - therapeutic use; Cortisone - therapeutic use; Desoxycorticosterone - therapeutic use; Dihydroergotoxine - therapeutic use; Dogs; Drug Therapy, Combination; Humans; Respiratory Insufficiency - etiology; Shock, Surgical - blood; Shock, Surgical - complications; Shock, Surgical - drug therapy; Thrombosis - etiology; Water-Electrolyte Imbalance
• ISSN: 0377-5003

In cases with postoperative shock and collapse a constant fall in the concentration of serum cathecholamines was noted. Thus adrenalin was reduced by 77%, noradrenalin by 86.5%, in direct proportion with the fall in the blood pressure, of the pulse amplitude and with the slowing-down (or the arrest) of the microcirculation. The reduction of serum cathecholamines also coincided with a decrease in the amount of buffer bases and of the diuresis. The adrenocortical vasopresor sympathicolithic mixture is indicated in the prolonged arterial hypotension following failure of therapy aimed at filling of the vascular bed associated with the administration of sympathicolytic drugs.