Changes of the renin-angiotensin-aldosterone system under contraceptive steroids. Contribution to the etiology of hypertension under hormonal contraceptives

Treatment with hormonal contraceptives leads to a considerable stimulation of the renin-angiotensin-aldosterone-system. First of all, there is a 2,5- to 4fold increase of renin substrate synthesis in the liver. As a consequence, more angiotensin I and angiotensin II are released. Angiotensin II stim...

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Bibliographic Details
Published inFortschritte der Medizin Vol. 94; no. 33; p. 1925
Main Authors Kaulhausen, H, Klingsiek, L, Breuer, H
Format Journal Article
LanguageGerman
Published Germany 18.11.1976
Subjects
Adult
Aldosterone - blood
Angiotensin II - blood
Contraceptives, Oral - adverse effects
Contraceptives, Oral, Hormonal - adverse effects
Endopeptidases - biosynthesis
Female
Humans
Hypertension - chemically induced
Liver - metabolism
Protein Binding
Renin - blood
Hypertension > etiology
Renin-angiotensin-aldosterone Effects
Vascular Diseases
Oral Contraceptives > side effects
Homeostasis
Biology
Contraception
Physiology
Contraceptive Methods > side effects
Family Planning
Diseases
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Summary:Treatment with hormonal contraceptives leads to a considerable stimulation of the renin-angiotensin-aldosterone-system. First of all, there is a 2,5- to 4fold increase of renin substrate synthesis in the liver. As a consequence, more angiotensin I and angiotensin II are released. Angiotensin II stimulates the secretion of aldosterone in the adrenals, thus producing a higher aldosterone concentration in plasma. The urinary excretion of aldosterone is elevated to a lesser degree, probably because of the simultaneously increased binding of aldosterone to plasma proteins. The release of renin is suppressed to 50% by negative feedback mechanisms. Some possible factors in the etiology of hypertension induced by oral contraceptives are discussed.
ISSN:0015-8178