Analysis of apomorphine aggessiveness and stereotypy: role of serotonin- and cholinergic systems of the brain

In male albino rats the electrolytic lesions of the dorsal and median raphe nuclei of the mesencephalon diminished apomorphine-induced aggressiveness (number of attacks, aggressive posture latencies) but didn't influence significantly the intensity of the stereotypy. Both the blockator of trypt...

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Bibliographic Details
Published inZurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 27; no. 6; p. 1303
Main Authors Zharkovskiĭ, A M, Allikmets, K Kh
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.11.1977
Subjects
Acetylcholine - metabolism
Aggression - drug effects
Aggression - physiology
Animals
Apomorphine - pharmacology
Atropine - pharmacology
Behavior, Animal - drug effects
Brain - drug effects
Brain Chemistry - drug effects
Dopamine - analysis
Fenclonine - pharmacology
Homovanillic Acid - analysis
Humans
Hydroxyindoleacetic Acid - analysis
Male
Norepinephrine - analysis
Physostigmine - pharmacology
Raphe Nuclei - physiology
Rats
Reaction Time
Serotonin - metabolism
Stereotyped Behavior - drug effects
Stereotyped Behavior - physiology
Tryptophan - pharmacology
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Summary:In male albino rats the electrolytic lesions of the dorsal and median raphe nuclei of the mesencephalon diminished apomorphine-induced aggressiveness (number of attacks, aggressive posture latencies) but didn't influence significantly the intensity of the stereotypy. Both the blockator of tryptophane hydroxylase parachlorophenylamine (PCPA) and 1-tryptophane did not exert any influence on behavioral effects of apomorphine. The raphe-lesion as well as PCPA decreased the level of serotonin and 5-hydroxyindoleacetic acid in the rat forebrain. PCPA decreased in raphe-lesioned rats the dopamine level too. M-cholinoblocking agent atrophine enhanced apomorphine-induced aggressiveness and stereotypy. The blockator of cholinesterase physostigmine had opposite effects. The results suggest that apomorphine induced aggressiveness depends on serotoninergic and cholinergic activity in the brain and there exists a functional link between these neuromediator systems in the CNS.
ISSN:0044-4677