Role of arterio-arterial embolisms in the pathogenesis of cerebral circulatory disorders

• Published in: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) Vol. 78; no. 3; p. 357
• Main Authors: Lunev, D K, Romasenko, M V, Kniazeva, G R, Kutchak, E N, Bragina, L K
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 1978
• Subjects: Adult; Aged; Aspirin - therapeutic use; Basilar Artery; Blood Coagulation; Carotid Arteries; Carotid Artery Diseases - complications; Cerebral Arteries - pathology; Constriction; Female; Humans; Intracranial Arteriosclerosis - complications; Intracranial Embolism and Thrombosis - etiology; Intracranial Embolism and Thrombosis - pathology; Ischemic Attack, Transient - etiology; Ischemic Attack, Transient - pathology; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Vertebral Artery
• ISSN: 0044-4588

The authors studied 52 patients with brain infarctions and transient disorders of cerebral circulation, which in the opinion of the authors developed as a result of arterio-arterial embolism. Besides, 16 post-mortem cases with arterio-arterial embolism were studied as well. On the basis of clinico-angiographical, clinico-laboratory and clinico-anatomical correlations, the authors come to the conclusion that this mechanism is frequently the main link in the pathogenesis of distrubed cerebral circulation. Embologenic materials in the development of brain infarctions are most often particles of parietal or obturating thrombi in the magistral cerebral vessels. In patients with transient disorders of cerebral circulation most likely embolism of the minor cerebral vessels by thrombocytic aggregates. The authors discuss the functional properties of thrombocytes in the pathogenesis of transient disorders of cerebral circulation and the feasibility of the use of antiaggregates for preventive purposes.