Radiotherapy with 131J and 125J of Basedow's disease. Indications and results relative to the incidence of post-actinic hypothyroidism

The indications for radioisotope management in Basedow's disease and the complications involved are explained. Particular reference is made to the possibility of early or late hypothyroidism when 131I and 125I are employed for this purpose. The physiopathogenetic bases for this are examined in...

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Bibliographic Details
Published inMinerva medica Vol. 70; no. 2; p. 135
Main Authors Dradi, C, Riceputi, G, Biagioli, R, Riva, P
Format Journal Article
LanguageItalian
Published Italy 14.01.1979
Subjects
Adult
Aged
Female
Follow-Up Studies
Graves Disease - radiotherapy
Humans
Hypothyroidism - etiology
Iodine Radioisotopes - adverse effects
Iodine Radioisotopes - therapeutic use
Male
Middle Aged
Radiotherapy Dosage
Thyroid Gland - anatomy & histology
Thyroxine - analysis
Triiodothyronine - analysis
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Summary:The indications for radioisotope management in Basedow's disease and the complications involved are explained. Particular reference is made to the possibility of early or late hypothyroidism when 131I and 125I are employed for this purpose. The physiopathogenetic bases for this are examined in relation to dosage and early diagnosis. Results obtained with small doses (fractionated in some cases) of these isotopes in 126 patients with thyrotoxicosis. One-year and later follow-up was directed to the clinical and functional responses to treatment in the light of age, sex, T4, maximum uptake, eff. T/2, thyroid size, and doses administered. Recurrences were rather frequent and further doses were given. However, early hypothyroidism was very rare. This appeared to be related to the dose administered and inversely to gland size. The results are compared with those in the literature.
ISSN:0026-4806