Effect of differentiation of GABA levels in various cell cultures

The effect of factors inducing somatic differentiation on cellular GABA level has been investigated. C6 glial cells from a rat astrocytoma present a significantly higher GABA level than the other glial or neuronal cells studied. A significant decrease in GABA levels in most cases parallels the somat...

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Bibliographic Details
Published inComptes rendus des seances de la Societe de biologie et de ses filiales Vol. 171; no. 5; p. 1116
Main Authors Simler, S, Gensburger, C, Ciesielski, L, Mandel, P
Format Journal Article
LanguageFrench
Published France 1977
Subjects
Aminobutyrates - analysis
Animals
Astrocytes - analysis
Bucladesine - pharmacology
Cell Differentiation
Cell Line - drug effects
Clone Cells - analysis
Cricetinae
Fetal Blood
gamma-Aminobutyric Acid - analysis
Mice
Neuroglia - analysis
Neurons - analysis
Rats
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Summary:The effect of factors inducing somatic differentiation on cellular GABA level has been investigated. C6 glial cells from a rat astrocytoma present a significantly higher GABA level than the other glial or neuronal cells studied. A significant decrease in GABA levels in most cases parallels the somatic differentiation induced either by withdrawal of fetal serum, or by addition of dibutyryl cyclic AMP to the culture medium.
ISSN:0037-9026