Intraoperative damage to the myocardium and heart failure upon radical correction of the tetralogy of Fallot

The ultrastructure of contractile myocardium at the stages of anoxia and after switching in the coronary circulation was studied on the material of 128 biopsies of the myocardium from 51 patients with Fallot's tetrad operated radically under conditions of artificial circulation and anoxic cardi...

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Bibliographic Details
Published inArkhiv patologii Vol. 41; no. 8; p. 23
Main Authors Kniazeva, G D, Sheremet'eva, G F, Konstantinov, B A, Kostriukov, B M, Liubarskaia, A D
Format Journal Article
LanguageRussian
Published Russia (Federation) 1979
Subjects
Adolescent
Adult
Child
Child, Preschool
Extracorporeal Circulation
Heart Failure - complications
Heart Failure - pathology
Humans
Microscopy, Electron
Mitochondria, Heart - ultrastructure
Myocardium - ultrastructure
Postoperative Complications
Tachycardia - complications
Tetralogy of Fallot - complications
Tetralogy of Fallot - pathology
Tetralogy of Fallot - surgery
Ventricular Fibrillation - complications
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Summary:The ultrastructure of contractile myocardium at the stages of anoxia and after switching in the coronary circulation was studied on the material of 128 biopsies of the myocardium from 51 patients with Fallot's tetrad operated radically under conditions of artificial circulation and anoxic cardiac arrest. Heterogeneity of cell organelles damage made it difficult to evaluate myocardial injury on the whole. To make morphological data more objective, a geometric method of quantitative analysis was used which permitted to distinguish two groups of damage and to correlate them with the pattern of cardiac activity restoration and the course of the postoperational period. The results indicate some relationship between changes in the ultrastructure of mitochondria and the development of cardiac insufficiency in patients with Fallot's tetrad.
ISSN:0004-1955