2-Acetyl-2-methyl-1-phenyl-hydrazine: a frequently occuring artifact in processing biological material after ingestion of drugs containing antipyrine (author's transl)

4-Hydroxy-antipyrine, the main metabolite of antipyrine is decomposed in alkaline medium to 2-acetyl-2-methyl-1-phenyl-hydrazine. Consequently this compound is often found in the working up of antipyrine-containing drugs.

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 27; no. 2; p. 355
Main Authors Zietz, E, Spiteller, G
Format Journal Article
LanguageGerman
Published Germany 01.02.1977
Subjects
Antipyrine - analysis
Antipyrine - metabolism
Chemical Phenomena
Chemistry
Chromatography, Gas
Magnetic Resonance Spectroscopy
Mass Spectrometry
Phenylhydrazines - analysis
Spectrophotometry, Ultraviolet
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Summary:4-Hydroxy-antipyrine, the main metabolite of antipyrine is decomposed in alkaline medium to 2-acetyl-2-methyl-1-phenyl-hydrazine. Consequently this compound is often found in the working up of antipyrine-containing drugs.
ISSN:0004-4172