Acute leukemia in multiple myeloma: case histories, a review of the literature and assessment of the incidence

The results of a follow-up study of 112 patients with multiple myeloma are presented. Three of these patients developed acute leukaemia during the respective period of clinical observation (maximum: 11 years)--one case of acute myeloblastic leukaemia, myelomonocytic leukaemia and erythroleukaemia, r...

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Bibliographic Details
Published inKlinische Wochenschrift Vol. 57; no. 15; p. 769
Main Authors Bierbach, H, Zeile, G, Wellek, S, Fischer, J
Format Journal Article
LanguageGerman
Published Germany 01.08.1979
Subjects
Acute Disease
Aged
Female
Humans
Leukemia - mortality
Leukemia - pathology
Leukemia, Erythroblastic, Acute - pathology
Leukemia, Monocytic, Acute - pathology
Leukemia, Myeloid, Acute - pathology
Male
Melphalan - therapeutic use
Middle Aged
Multiple Myeloma - drug therapy
Multiple Myeloma - mortality
Multiple Myeloma - pathology
Probability
Time Factors
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Summary:The results of a follow-up study of 112 patients with multiple myeloma are presented. Three of these patients developed acute leukaemia during the respective period of clinical observation (maximum: 11 years)--one case of acute myeloblastic leukaemia, myelomonocytic leukaemia and erythroleukaemia, respectively. For estimating the incidence of acute leukaemia in the presence of multiple myeloma an extended life table method was applied. On the basis of our data this method gave a probability of 5.9% for a patient to develop acute leukaemia at any time after the diagnosis of multiple myeloma. In a statistical discussion this result is considered to confirm the assumption of a highly increased AL-risk in patients with multiple myeloma. In a survey of the literature some important data of 100 cases with the association acute leukaemia--multiple myeloma are reported.
ISSN:0023-2173