The anti-inflammatory profile of proquazone

Proquazone, 1-isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone is an orally effective anti-inflammatory analgesic and antipyretic compound in animal models. The compound is less ulcerogenic than indomethacin in the rat and appears to potentiate the anti-inflammatory and thymus involution effects of h...

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Bibliographic Details
Published inArchives internationales de pharmacodynamie et de thérapie Vol. 221; no. 1; p. 122
Main Authors Takesue, E I, Perrine, J W, Trapold, J H
Format Journal Article
LanguageEnglish
Published Belgium 01.05.1976
Subjects
Analgesics
Animals
Anti-Inflammatory Agents
Arthritis, Rheumatoid - drug therapy
Female
Granuloma - drug therapy
Indomethacin - adverse effects
Indomethacin - therapeutic use
Male
Quinazolines - adverse effects
Quinazolines - therapeutic use
Rats
Stomach Ulcer - chemically induced
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ISSN0003-9780

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Summary:Proquazone, 1-isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone is an orally effective anti-inflammatory analgesic and antipyretic compound in animal models. The compound is less ulcerogenic than indomethacin in the rat and appears to potentiate the anti-inflammatory and thymus involution effects of hydrocortisone in this species. That a nonacidic nonsteroidal compound would display a spectrum of anti-inflammatory activity similar to that previously found only with acidic compounds will be the subject of further investigations.
ISSN:0003-9780