Role of macrophages and foreign body type giant cells in the biodestruction process of polyurethane adhesive tissue

The biodestruction process of polyurethane adhesive was investigated in application to intestine anastomoses, wounds of skeletal muscles and surfaces of some internal organs. The polymer destruction was proved to be connected with the activity of giant cells of foreign body type and macrophages phag...

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Published inPolimery w medycynie Vol. 7; no. 2; p. 105
Main Authors Pkhakadze, G A, Tereshchenko, T L, Iatsenko, V P, Kolomiĭtsev, A K
Format Journal Article
LanguageRussian
Published Poland 1977
Subjects
Animals
Macrophages - physiology
Phagocytosis
Polyurethanes
Rabbits
Tissue Adhesives
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Summary:The biodestruction process of polyurethane adhesive was investigated in application to intestine anastomoses, wounds of skeletal muscles and surfaces of some internal organs. The polymer destruction was proved to be connected with the activity of giant cells of foreign body type and macrophages phagocyting the micromolecules of the adhesive. The presence of adhesive microfragments in macrophages and giant cells was ascertained on the basis of a method elaborated by the authors consisting in staining of the polyurethane adhesive with Sudan III-IV. Moreover, it was pointed out, that biodestruction products had no negative effect in the regeneration of nervous and muscle fibers.
ISSN:0370-0747