Combination of chemotherapy and radiotherapy. II. Differential effect on the medullary syndrome of irradiation combined with the drug administered in fractional doses and at various times

We have studied the effect of 5-Fu in fractional doses on the medullar syndrome after a single whole body cobalt irradiation in mice. The bone marrow is not sensitive to the fractionation of 5-Fu and it is the single dose of 5-Fu injected 72 hours after the irradiation which is the most effective.

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Bibliographic Details
Published inComptes rendus des seances de la Societe de biologie et de ses filiales Vol. 173; no. 1; p. 161
Main Authors Maisin, H, Anckaert, M A, Van Evercoren, A, De Coster, B M
Format Journal Article
LanguageFrench
Published France 1979
Subjects
Animals
Bone Marrow Diseases - drug therapy
Bone Marrow Diseases - radiotherapy
Drug Administration Schedule
Female
Fluorouracil - administration & dosage
Lethal Dose 50
Mice
Mice, Inbred BALB C
Time Factors
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Summary:We have studied the effect of 5-Fu in fractional doses on the medullar syndrome after a single whole body cobalt irradiation in mice. The bone marrow is not sensitive to the fractionation of 5-Fu and it is the single dose of 5-Fu injected 72 hours after the irradiation which is the most effective.
ISSN:0037-9026