Comparison of the efficacy of parenteral and enteral pertussis immunization in the rabbit (author's transl)

The effects of immunization with inactivated B. pertussis were studied in the rabbit using enteral (oral and via suppositories) and parenteral immunization routes. The rise in agglutinating and complement-binding immunoglobulins in the rabbit serum was about equal following immunization by supposito...

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Bibliographic Details
Published inWiener Klinische Wochenschrift Vol. 89; no. 11; p. 386
Main Authors Höfler, K H, Binder, B, Koch, M
Format Journal Article
LanguageGerman
Published Austria 27.05.1977
Subjects
Administration, Oral
Animals
Antigens, Bacterial - analysis
Injections, Intramuscular
Pertussis Vaccine - administration & dosage
Rabbits
Saliva - analysis
Suppositories
Whooping Cough - prevention & control
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Summary:The effects of immunization with inactivated B. pertussis were studied in the rabbit using enteral (oral and via suppositories) and parenteral immunization routes. The rise in agglutinating and complement-binding immunoglobulins in the rabbit serum was about equal following immunization by suppository and parenteral administration, but the demonstration of local immunity (immunoglobulins reacting with B. pertussis in salive) by immunofluorescence methods was observed only in the group immunized with enterally-administered B. pertussis.
ISSN:0043-5325