Multiphasic regulatory system mediating the effect of estradiol in rat uterus

Estradiol is shown to induce histidine decarboxylase and histamine to activate adenylate cyclase in the rat uterus. Cyclic AMP like histamine simulates the effect of estradiol, intensifying RNA synthesis and inducing glycolytic enzymes and uterus inhibition. It was found by autoradiography that 3H-e...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 88; no. 9; p. 349
Main Authors Salganik, R I, Pankova, T G, Deribas, V I, Igonina, T M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1979
Subjects
Adenylyl Cyclases - metabolism
Animals
Carboxy-Lyases - metabolism
Cyclic AMP - metabolism
Cyclic AMP - pharmacology
Estradiol - pharmacology
Female
Glycolysis - drug effects
Histamine - metabolism
Histamine - pharmacology
Histidine Decarboxylase - metabolism
Myometrium - metabolism
Rats
Receptors, Cyclic AMP - metabolism
Receptors, Histamine - metabolism
RNA - biosynthesis
Uterus - drug effects
Uterus - metabolism
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Summary:Estradiol is shown to induce histidine decarboxylase and histamine to activate adenylate cyclase in the rat uterus. Cyclic AMP like histamine simulates the effect of estradiol, intensifying RNA synthesis and inducing glycolytic enzymes and uterus inhibition. It was found by autoradiography that 3H-estradiol is accepted by the nuclei of some myometrium cells, 3H-histamine by their cytoplasm and 3H-cAMP is selectively bound by endothelium cells of the uterus capillaries. The estradiol messengers (histamine and cAMP) seem to mediate hormonal effect of some uterus heterofunctional cells forming a kind of multicellular functional system.
ISSN:0365-9615